Transcranial magnetic stimulation for the treatment of headache
Keywords:
headache, migraine, rTMS, spTMS, stimulation, treatmentAbstract
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation method. It can be applied either by using single pulses – single pulse TMS (spTMS) or by consecutive trains of pulses - repetitive TMS (rTMS). Various TMS protocols have been used with mixed results in a significant number of patients with headache. The aim of this article is to analyze the results from the available studies. Most of the publications investigate patients with migraine. The results from most of the studies so far show that: 1) TMS is well tolerated in headache; 2) spTMS is likely to have effect in the treatment of migraine attack (with and without aura); 3) high frequency rTMS over the primary motor cortex and the left dorsolateral cortex is likely to have effect in the prevention of migraine. There is considerably less data for the role of TMS in the treatment of other types of headaches.
References
[Shirshova, E. V., Akarachkova, E. S. Primenenie na magnitnata transkranialna stimulatsiya pri khronichna golovna bolka. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2012, 112, 7, 62-64.]
Almaraz, A. C., Dilli, E., Dodick, D. W. The effect of prophylactic medications on TMS for migraine aura. Headache, 2010, 50, 10, 1630-1633.
Andreou, A. P., Sprenger, T., Goadsby, P. J. Cortical modulation of thalamic function during cortical spreading depression - unraveling a new central mechanism involved in migraine aura. J. Headache Pain, 2013, 14, 1S, I6.
Bhola, R., Kinsella, E., Giffin, N., Lipscombe, S., Ahmed, F., Weatherall, M, Goadsby, P. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. The Journal of Headache and Pain, 2015, 16, 51.
Bhola, R., Kinsella, E., Weatherby, S., Ahmed, F., Giffin, N., Maniyar, F., Goadsby, P.J. Use of single pulse TMS (STMS) to treat migraine with medication overuse. Cephalalgia, 2015, 35, 6S, 24.
Brighina, F., Cosentino, G., Fierro, B. Brain stimulation in migraine. In: Handbook of Clinical Neurology Vol. 116 (3rd series), Lozano A. M., Hallett M, eds., Elsevier, 2013, 585-98.
Brighina, F., Palermo, A., Daniele, O., Aloisio, A., Fierro, B. High-frequency transcranial magnetic stimulation on motor cortex of patients affected by migraine with aura: a way to restore normal cortical excitability? Cephalalgia, 2010, 30, 1, 46-52.
Brighina, F., Piazza, A., Daniele, O., Fierro, B. Modulation of visual cortical excitability in migraine with aura: effects of 1 Hz repetitive transcranial magnetic stimulation. Exp. Brain Res., 2002, 145, 2, 177-181.
Brighina, F., Piazza, A., Vitello, G., Aloisio, A., Palermo, A., Daniele, O., Fierro, B. rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study. J. Neurol Sci., 2004, 227, 1, 67-71.
Brüggenjürgen, B., Baker, T., Bhogal, R., Ahmed, F. Cost impact of a non-invasive, portable device for patient self-administration of chronic migraine in a UK National Health Service setting. Springerplus, 2016, 5, 1, 1249.
Clarke, BM., Upton, A. R., Kamath, M. V., Al-Harbi, T., Castellanos, C. M. Transcranial magnetic stimulation for migraine: clinical effects. J. Headache Pain, 2006, 7, 5, 341-346.
Conforto, A. B., Amaro, E. Jr., Gonçalves, A. L., Mercante, J. P., Guendler, V. Z., Ferreira, J. R., Kirschner, C. C., Peres, M. F. Randomized, proof-of-principle clinical trial of active transcranial magnetic stimulation in chronic migraine. Cephalalgia, 2014, 34, 6, 464-472.
Coppola, G., De Pasqua, V., Pierelli, F., Schoenen, J. Effects of repetitive transcranial magnetic stimulation on somatosensory evoked potentials and high frequency oscillations in migraine. Cephalalgia, 2012, 32, 9, 700-709.
Coppola, G., Pierelli, F., Schoenen, J. Habituation and migraine. Neurobiol Learn Mem, 2009, 92, 2, 249–259.
Coppola, G., Pierelli, F., Schoenen, J. Is the cerebral cortex hyperexcitable or hyperresponsive in migraine? Cephalalgia, 2007, 27, 12, 1427-1439.
D’Elia, T. S, Vigano, A., Likale, M. F., Sava, S. L., Schoenen, J., Magis, D. Quadripulse Repetitive Transcranial Magnetic Stimulation on Visual Cortex for Chronic Migraine Prevention: A Pilot-Trial. Cephalalgia, 2013, 33, 8S, 49.
Ekizoglu, E., Sozer-Topçular, N., Baykan, B., Oge, A. E. Assessment of excitability at the brainstem and cortex in primary headaches with allodynia. J. Clin. Neurophysiol., 2015, 32, 2, 119-129.
Emara, T., Amin, R., Hamed, S., Salah-eldin, N., Hemeda, M., Ashour, S. Half reduction in number of attacks in episodic migraine with left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation (rTMS). A randomized controlled study. Cephalalgia, 2015, 35, 6S, 43
George, M., Taylor, J. Theoretical Basis for Transcranial Magnetic Stimulation. In: A Clinical Guide to Transcranial Magnetic Stimulation, Holtzheimer P, McDonald W., eds., New York: Oxford University Press, 2014, 1-7.
Goadsby, P. J. Recent advances in understanding migraine mechanisms, molecules and therapeutics. Trends. Mol. Med., 2007, 13, 1, 39–44.
Granato, A., Ilbeh, S М., Trovò, F., Borelli, M., Granello, G., Semenic, M., Monti, F., Pizzolato, G. Transcranial magnetic stimulation as a new approach in medication overuse headache: a pilot study. J. Headache Pain, 2013, 14, 1S, 168.
Hodaj, H., Alibeu, J. P., Payen, J. F., Lefaucheur, J. P. Treatment of Chronic Facial Pain Including Cluster Headache by Repetitive Transcranial Magnetic Stimulation of the Motor Cortex With Maintenance Sessions: A Naturalistic Study. Brain Stimul., 2015, 8, 4, 801-807.
Holland, P. R., Schembri, C., Fredrick, J., Goadsby, P. J. Transcranial magnetic stimulation for the treatment of migraine aura? Cephalalgia, 2009, 29, 1S, 22.
Lefaucheur, J-P et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin. Neurophysiol., 2014, 125, 11, 2150-2206.
Libera, D. D., Colombo, B., Nuara, A., Spagnolo, F., Straffi, L., Chieffo, R., Coppi, E., Di Maggio, G., Ferrari, L., Houdayer, E., Velikova, S., Zangen, A., Comi, G., Leocani, L. Repetitive Transcranial Magnetic Stimulation (rTMS) as Preventive Treatment of Chronic Migraine: A Safe Approach with a Promising Effect. Neurology, 2013, 80, 7, S59.005
Lipton, R. B., Dodick, D. W., Silberstein, S. D., Saper, J. R., Aurora, S. K., Pearlman, S. H., Fischell, R. E., Ruppel, P. L., Goadsby, P. J. Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial. Lancet Neurol., 2010, 9, 4, 373-380.
Lorenz, J., Minoshima, S., Casey, K. L. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain, 2003, 126, 5, 1079-1091.
Misra, U. K., Kalita, J. et al. Is β endorphin related to migraine headache and its relief? Cephalalgia, 2013, 33, 5, 316-322.
Misra, U. K., Kalita, J., Bhoi, S. K. High-rate repetitive transcranial magnetic stimulation in migraine prophylaxis: a randomized, placebo-controlled study. J. Neurol., 2013, 260, 11, 2793-2801.
Mohammad, Y. M., Hughes, G., Krumah, M. N., Fischell, S., Fischell, R., Ruppel, R., Schweiger, J. Self-administered transcranial magnetic stimulation (TMS) during the aura phase improves and aborts migraine headache. European Journal of Neurology, 2006, 13, 247.
Mohammad, Y. M., Kothari, R., Hughes, G., Krumah, M. N., Fischell, S., Fischell, R., Schweiger, J., Ruppel, P. Transcranial magnetic stimulation (TMS) relieves migraine headache. European Journal of Neurology, 2006, 13, 2S, 23.
Osenbach, R. K. Motor cortex stimulation for intractable pain. Neurosurg. Focus, 2006, 21, 6, E7.
Richards E. M, Payne J. L. The management of mood disorders in pregnancy: alternatives to antidepressants. CNS Spectr., 2013, 18, 5, 261-271.
Rossi, S., Hallett, M., Rossini, P. M., Pascual-Leone, A. Safety of TMS Consensus Group. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin. Neurophysiol., 2009, 120, 12, 2008-2039.
Scatena, P., Sette, G., Rapinesi, C., Kotzalidis, G. D., Ferri, V. R., Di Pietro, S., Raccah, R. N., Ferracuti, S., Orzi, F., Girardi, P. Improved chronic migraine after DTMS. The Journal of Headache and Pain, 2014, 15, 1S, 99.
Starling, A. J., Scottsdale, A. Z, Dodick, R. P. et al. Comparison of effect size between active and placebo single pulse transcranial magnetic stimulation (spTMS) versus triptans for the acute treatment of migraine. Neurology, 2011, 76, 9, A441.
Teepker, M., Hötzel, J., Timmesfeld, N., Reis, J., Mylius, V., Haag, A., Oertel, W. H., Rosenow, F., Schepelmann, K. Low-frequency rTMS of the vertex in the prophylactic treatment of migraine. Cephalalgia, 2010, 30, 2, 137-144.
Teo, W. P., Kannan, A., Loh, P. K., Chew, E., Sharma, V. K., Chan, Y. C. Poor Tolerance of Motor Cortex rTMS in Chronic Migraine. J. Clin. Diagn. Res., 2014, 8, 9, MM01- MM02.
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Copyright (c) 2016 Vasil Todorov, D. Bogdanova, I. Milanov
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